PHARMACOLOGY WITH PRANJAL (LETS MAKE PHARMACOLOGY EFFORTLESSS)

 **Definition and Types of Receptors in Pharmacology** In pharmacology, receptors are fundamental components of biological systems that mediate the effects of drugs and endogenous signaling molecules. Receptors can be conceptualized as molecular switches that, upon activation by specific ligands, initiate cellular responses, leading to physiological effects. Understanding the diversity and mechanisms of action of receptors is crucial for drug discovery, development, and therapeutic interventions. This article explores the definition, classification, and significance of receptors in pharmacology. **Definition of Receptors** Receptors are specialized protein molecules located on the surface of cells, within cells, or in extracellular spaces. They bind selectively to specific ligands, such as drugs, neurotransmitters, hormones, or other signaling molecules, initiating a cascade of intracellular events that ultimately result in physiological responses. The binding of a ligand to its re...

    1. Introduction      Pharmacology, the study of drugs and how they interact with the body, plays a crucial role in modern healthcare. As technology continues to advance at an unprecedented rate, the marriage of pharmacology and artificial intelligence (AI) has become a hot topic in the medical field. AI has the potential to revolutionize drug discovery, patient care, and clinical decision-making. In this blog, we will delve deep into the world of pharmacology and explore how AI is transforming this important field. Whether you are a healthcare professional or simply interested in the latest advancements in medicine, this article will provide a comprehensive understanding of the potential of AI in pharmacology. 2. The role of artificial intelligence in pharmacology Artificial Intelligence (AI) has emerged as a game-changer in the field of pharmacology. By harnessing the power of machine learning and data analysis, AI has the potential to transform various asp...

HOW METHOTREXATE WORKS?          Developed over 70 years ago as an anti-folate chemotherapy agent, methotrexate (MTX) is a WHO ‘essential medicine’ that is now widely employed as a first-line treatment in auto-immune, inflammatory diseases such as rheumatoid arthritis (RA), psoriasis, and Crone's disease. When used for these diseases patients typically take a once-weekly low-dose of MTX — a therapy that provides effective inflammatory control to tens of millions of people worldwide.  MTX is a methyl derivative of aminopterin and acts as an immunosuppressant. It is an analog of folic acid and inhibits dihydrofolate reductase (DHFR).                                                    DHFR is an essential enzyme for the synthesis of nucleotides. Folic acid from the diet is converted into dihydrofolate (DHF) and it is again converted...